About Us

Integrated Sensing Systems (ISS) headquarters in Ypsilanti, MI. ISS produces density meters, density measuring instruments, and density sensors for both liquid and gas for a variety of industries.


The mission of Integrated Sensing Systems, (ISS) is to deliver a high accuracy and repeatable density measurement device that exceeds our customer’s expectations.

“Integrated sensing systems has dedicated itself to improving the world, one small measurement at a time, by commercializing the tremendous potential of MEMS in both industrial and life science applications.”


Founders Dr. Nader Najafi, Dr. Ken Wise, and Dr. Khalil Najafi established Integrated Sensing Systems in January 1995 to design, develop, manufacture and commercialize innovative products based on high performance microelectromechanical systems (MEMS). Initially the company transferred over 20 years of R&D from the University of Michigan through exclusively licensing 6 patents. Over the years Integrated Sensing Systems has developed a deep base of intellectual properties in order to design and manufacture cutting-edge products based on MEMS technology. Currently the company’s IP includes over 50 issued patents and several more pending patents. There is a great deal of know-how and trade secrets that goes into the fluidic product line with MEMS inside. The Integrated Sensing Systems fluidic product offering includes:

  • In line, real-time fluidic density meters and density sensors for both gases and liquids
  • Embedded sensors for measuring density of gases and liquids: methanol concentration, sugar concentration, and other binary concentration measurement
  • Analytical and laboratory instruments
  • System level solutions

Coriolis Technology

The Integrated Sensing Systems fluidic products are based on coriolis technology that is miniaturized to a micro level. The vibrational resonance of the sensing tube is used to measure the density of the fluid in the sensor. The sensing tube is made from silicon. Silicon is an ideal material to fabricate the sensing tube since silicon is lighter, stronger, and has a greater thermal conductivity. The Integrated Sensing Systems microCoriolis sensor is a core technology used in all fluidic products.

The Integrated Sensing Systems product advantage:

  • High accuracy & precision
  • Small footprint reduces cost & installation requirements
  • Real-time response
  • Not impacted by environmental vibration

This sensor is fabricated using the combination of high volume silicon manufacturing technology and traditional Coriolis sensor design principles. Integrated Sensing Systems produces these sensors using an in-house state of the art MEMS fabrication facility. Integrated Sensing System has a Class 100 state of the art Clean Room for MEMS manufacturing.

The company also has an on-premise manufacturing facility that is ISO 9001: 2008 Certified Registered FM 82840 and ISO 13485: 2003 Registered FM 570652.






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TitlePatent #Date of Patent
Fluid Sensing Device with Integrated Bypass and Process Therefore4,568,7638/13/2010
Method for Packaging Microsensors6,140,14410/31/2000
Micromachined Fluidic Apparatus6,477,90111/12/200
Methods for Prevention Reduction, and Elimination of Outgassing and Trapped Gases in Micromachined Devices6,499,35412/31/2002
Micromachined Fluid Analysis Device and Method 6,637,25710/28/2003
Integrated Microtube Sensing Device6,647,77811/18/2003
Sensing Catheter System and Method of Fabrication6,824,52111/30/2004
Process of Forming a Microneedle and Microneedle Formed Thereby6,844,2131/18/2005
Method of Forming a Reactive Material and Article Formed Thereby6,923,6258/2/2005
Wireless MEMS Capacitive Sensor for Physiologic Parameter Measurement6,926,6708/9/2005
Fluid Delivery System and Method - (Combination of provisional patents IPF-12 and IPF-18)6,932,1148/23/2005
Method of Fabricating a Micromachined Tube for Fluid Flow6,935,0108/30/2005
Micromachined Lysing Device and Method for Performing Cell Lysis 6,942,1699/13/2005
Implantable Sensing Device for Physiological Parameter Measurement 6,968,74311/29/2005
Resonant Tube Viscosity Sensing Device7,059,1766/13/2006
A System for Monitoring Conduit Obstruction7,211,0485/1/2007
Fluid Sensing Device with Integrated Bypass and Process Therefore 7,228,7356/12/2007
Fluid System and Method of Assessing a Property of a Fluid Flowing Therein 7,263,8829/4/2007
Anchor for Medical Implant Placement and Method of Manufacture7,317,9511/8/2008
Process of Making a Microtube and Microfluidic Devices Formed Therewith7,351,6034/1/2008
Device and Method for detecting and treating chemical and biological agents7,354,4294/8/2008
Process of Making a Microtube and Microfluidic Devices Formed Therewith. (Formerly - Improved Method of Making a Low Cost Microfluidic Device and Tube - A continuation in part of IFP-39)7,381,6286/3/2008
Device and Method for Sensing Rheological Properties of a Fluid (Formerly - Lubricity and viscosity sensing method and device)7,437,91210/21/2008
Sensing and Analysis System, Network, and Method Formerly: Portable Computer Interfaced Chemical Analysis Device7,483,8051/27/2009
Microfluidic Device 7,568,3998/4/2009
Microfluidic Device and Method of Operation7,581,4299/1/2009
A System for Monitoring the Physiologic Parameters of Patients with Congestive Heart Failure7,615,01011/10/2009
Microfluidic Device and Microtube Therefore7,628,08212/8/2009
Method and Anchor for Medical Implant Placement, and Method of Anchor Manufacture7,634,31912/15/2009
Wireless Device and System for Monitoring Physiologic Parameters7,686,7623/30/2010
Getter Device7,789,9499/7/2010
System and Method of Assessing a Property of a Flowing Fluid 7,823,44511/2/2010
Delivery System, Method and Anchor For Medical Implant Placement (Formerly - Improved Medical Device Delivery and Anchor Systems)7,860,57912/28/2010
Method of Treating a Bodily Fluid (Divisional of co-pending US patent application 11/160,403)7,879,2412/1/2011
Method for Monitoring a Physiologic Parameter of Patients with Congestive Heart Failure8,014,8659/6/2011
Fluid Delivery System & Sensing Unit Therefor8,016,7989/13/2011
Process of Fabricating Microfluidic Device Chips and Chips Formed Thereby (Formerly: Metalic Microfluidic Chip Attachment Method and Design)8,021,9619/20/2011
Microfluidic Device and Method of Operation 7,921,7374/12/2011
Minimally Invasive Procedure for Monitoring a Physiological Parameter within an Internal Organ8,322,34612/4/2012